Released on: August 13, 2008, 2:02 pm

Press Release Author: Assay Designs

Industry: Biotech

Press Release Summary: For over 15 years, Assay Designs has provided high quality
antibodies, proteins, and kits for the precise quantification of key small and large
molecule biomarkers in a variety of sample matrices and species. Since our merger
with Stressgen® Bioreagents in 2005, the Assay Designs portfolio of products has
included the full line of Stressgen brand kits and reagents, enabling researchers to
investigate biological pathways involved in the cellular response to stress.

Press Release Body: In February 2008, Assay DesignsT launched the Hsp70 High
Sensitivity EIA Kit (Cat. #EKS-715). This kit is for the accurate and specific
quantification of as little as 90 pg/mL of inducible Hsp70 in serum and plasma
samples from human, mouse, and rat origin. This assay does not significantly cross
react with other Hsp70 family members such as Hsc70 (Hsp73), Grp78, DnaK (E. coli),
or Hsp71 (M. tuberculosis) allowing for accurate and specific quantitation of Hsp70
in samples.

Assay Designs Hsp70 High Sensitivity EIA Kit is the only product commercially
available that is validated for the measurement of circulating Hsp70. This product
has been specifically optimized for use with serum and plasma, but has not been
extensively validated for use with other sample matrices. The Hsp70 High Sensitivity
EIA Kit features liquid color-coded reagents and a pre-coated 96 well plate that
save lab time and reduce error. There is no need for cumbersome Western blot
analysis of serum and plasma samples. A simple dilution of samples in the supplied
kit assay buffer allows for the higher throughput analysis of up to 39 samples in
duplicate per 96 wells in just 4.5 hours. As scientists we understand the critical
nature of your research and take every step to ensure that our products meet the
highest quality standards for sensitivity, specificity, and reproducibility so you
do not have to repeat experiments. Our goal is to help you Simplify Your Science®.

Hsp70 is a molecular chaperone whose expression is induced upon exposure of the cell
or organism to conditions of stress. It prevents protein aggregation and promotes
the refolding of proteins that become damaged in response to environmental insults,
pathogens, and disease. Its activity is essential for cellular survival and recovery
under stress conditions, as well as for the maintenance of normal cellular function
under non-stress conditions. Hsp70 has been implicated to play a role in a variety
of disease and physiological processes such as hyperthermia, hypertension, toxic
exposure to chemical agents, hypoxia, ischemia, inflammation, autoimmunity,
apoptosis, cancer, organ transplantation, and bacterial and viral infections. Hsp70
is a key regulator of many normal physiological processes including aging,
spermatogenesis, menstruation, and physical activity such as exercise. The Assay
Designs High Sensitivity Hsp70 EIA kit is designed to evaluate and monitor Hsp70 in
these processes, and provides a key research tool for the investigation of Hsp70's
role in physiology and disease.


Web Site: http://www.assaydesigns.com

Contact Details: Emily Riesterer
Assay Designs, Inc.
5777 Hines Drive
Ann Arbor, MI 48108
800.833.8651
info@assaydesigns.com
www.assaydesigns.com